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Article

AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging

31 Mar 2013

Abstract excerpt

Even in healthy individuals there is an inexorable agerelated decline in cognitive function. This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular composition of the postsynaptic membrane. AMPA receptors (AMPARs) are glutamate-gated cation channels that mediate the overwhelming majority of fast excitatory transmission in the brain. Changes in AMPAR number and/or function...

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PMID: 23576886
DOI: 10.31887/dcns.2013.15.1/jhenley

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