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Contribution of 3D genome topological domains to genetic risk of cancers

2021-07-27

Abstract excerpt

Genome-wide association studies have identified statistical associations between various diseases, including cancers, and a large number of single-nucleotide polymorphisms (SNPs). However, they provide no direct explanation of the mechanisms underlying the association. Based on the recent discovery that changes in 3-dimensional genome organization may have functional consequences on gene regulation favoring diseas...

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Literature Corpus work
3eeff16e-4c71-5681-b1b5-a6b561b71bee
DOI
10.1101/2021.07.26.453813
Open publication

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Contribution of 3D genome topological domains to genetic risk of cancersDOI 10.1101/2021.07.26.453813
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