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Article

Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational study.

Human genomics - 11 Jan 2022

Jablonski Kim Philipp, Carron Leopold, Mozziconacci Julien, Forné Thierry, Hütt Marc-Thorsten, Lesne Annick

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified statistical associations between various diseases, including cancers, and a large number of single-nucleotide polymorphisms (SNPs). However, they provide no direct explanation of the mechanisms underlying the association. Based on the recent discovery that changes in three-dimensional genome organization may have functional consequences on gene...

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Identifiers

PMID: 35016721
DOI: 10.1186/s40246-022-00375-2
PMCID: PMC8753905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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