Article

The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D risk

2021-12-01

Abstract excerpt

Three-dimensional (3D) chromatin organization maps help to dissect cell type-specific gene regulatory programs. Furthermore, 3D chromatin maps have contributed to elucidating the pathogenesis of complex genetic diseases by connecting distal regulatory regions and genetic risk variants to their respective target genes. To understand the cell type-specific regulatory architecture of diabetes risk, we generated trans...

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Literature Corpus work: cb00a0d6-a658-5844-89fb-6a16911bef6a
DOI: 10.1101/2021.11.30.470653

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