Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure.

BMC genomic data - 17 Feb 2022

Osman Noha, Shawky Abd-El-Monsif, Brylinski Michal

Abstract excerpt

BACKGROUND: Numerous genome-wide association studies (GWAS) conducted to date revealed genetic variants associated with various diseases, including breast and prostate cancers. Despite the availability of these large-scale data, relatively few variants have been functionally characterized, mainly because the majority of single-nucleotide polymorphisms (SNPs) map to the non-coding regions of the human genome. The...

Topics

Join the communities discussing this publication.

Breast Neoplasms
Chromatin
Gene Expression Regulation, Neoplastic
Genome, Human
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 35176995
DOI: 10.1186/s12863-021-01021-x
PMCID: PMC8851830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure.PMID 35176995Read ↗

Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structureSemantic proximity Read ↗

Exploring the Effects of Genetic Variation on Gene Regulation in Cancer in the Context of 3D Genome StructureSemantic proximity Read ↗

Discover novel disease-associated genes based on regulatory networks of long-range chromatin interactions.Semantic proximity Read ↗

Contribution of 3D genome topological domains to genetic risk of cancersSemantic proximity Read ↗

GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications.Semantic proximity Read ↗

Leveraging three-dimensional chromatin architecture for effective reconstruction of enhancer-target gene regulatory networkSemantic proximity Read ↗

3DSNP: a database for linking human noncoding SNPs to their three-dimensional interacting genes.Semantic proximity Read ↗

Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome.Semantic proximity Read ↗

Maps of context-dependent putative regulatory regions and genomic signal interactions.Semantic proximity Read ↗

A comprehensive catalog of 3D genome organization in diverse human genomes facilitates understanding of the impact of structural variation on chromatin structureSemantic proximity Read ↗

Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational studySemantic proximity Read ↗

Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.