Article

Epigenetic germline variants predict cancer prognosis and risk and distribute uniquely in topologically associating domains

2023-09-01

Abstract excerpt

<h4>Background: </h4> Methylation quantitative trait loci (meQTLs) associate with different levels of local DNA methylation in cancers. Here, we investigated whether the distribution of cancer meQTLs reflected functional organization of the genome in the form of chromatin topologically associated domains (TADs) and evaluated whether cancer meQTLs near known driver genes have the potential to influence cancer risk...

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Literature Corpus work: 70823245-f27c-598c-9ad7-e3121d9b4bf0
DOI: 10.12688/f1000research.139476.1

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