Article

A 3D genome atlas of genetic variants and their pathological effects

2022-11-27

Abstract excerpt

The spatial architecture of the genome can be categorized into distinct layers. Each layer plays a critical role in transcriptional regulation and/or genomic integrity. Alterations at any level of the 3D genome can lead to an unwanted cascade of molecular events, which may ultimately drive the manifestation of disease. However, a comprehensive atlas of the mutations and structural genetic defects that affect genom...

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Literature Corpus work: de771213-e77c-5e96-97ae-c34a30034eea
DOI: 10.1101/2022.11.27.518071

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