Article

Protective <i>IFIH1</i> variant reduces immune-mediated islet stress and dysfunction in a type 1 diabetes genetic background

2025-12-31

Abstract excerpt

Genome-wide association studies (GWAS) have linked dozens of genetic loci to type 1 diabetes (T1D). The IFIH1 gene, which encodes the double-stranded RNA sensor MDA5, is one such locus. The E627* single nucleotide polymorphism (SNP) in IFIH1 is associated with protection against T1D, while the A946T variant is linked to increased risk. While the E627* variant has been shown to result in a truncated protein and d...

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Literature Corpus work: 3de28a90-cf6a-523e-aea8-d3dfd0cf6a85
DOI: 10.64898/2025.12.30.697107

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