Article

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner

2024-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic islet β-cells are attacked by the immune system, resulting in insulin deficiency and hyperglycemia. One of the top non-synonymous single-nucleotide polymorphisms (SNP) associated with T1D is in the interferon-induced helicase C domain-containing protein 1 ( IFIH1 ), which encodes an anti-viral cytosolic RNA sensor. This SNP resu...

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Literature Corpus work: 2a3824d8-c307-52fb-822d-75d3048faf75
DOI: 10.1101/2024.01.20.576482

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