Article

MDA5 and the integrated stress response control sex-specific type 1 diabetes onset in NOD mice

2026-07-07

Abstract excerpt

Type I diabetes (T1D) is an autoimmune disorder in which the insulin producing cells of the pancreas are attacked and destroyed by autoreactive T cells. The innate immune mechanisms that contribute to T1D remain incompletely defined. Genome-wide association studies in humans have identified alleles of the IFIH1 gene, which encodes the intracellular RNA sensor MDA5, that are strongly associated with development of...

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Literature Corpus work: 4f608f1d-0711-5944-85ae-a91b0687228f
DOI: 10.64898/2026.07.02.736190

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