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Article

An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.

Scientific reports - 21 Dec 2016

Domsgen Erna, Lind Katharina, Kong Lingjia, Hühn Michael H, Rasool Omid, van Kuppeveld Frank, Korsgren Olle, Lahesmaa Riitta, Flodström-Tullberg Malin

Abstract excerpt

The IFIH1 gene encodes the pattern recognition receptor MDA5. A common polymorphism in IFIH1 (rs1990760, A946T) confers increased risk for autoimmune disease, including type 1-diabetes (T1D). Coxsackievirus infections are linked to T1D and cause beta-cell damage in vitro. Here we demonstrate that the rs1990760 polymorphism regulates the interferon (IFN) signature expressed by human pancreatic islets following...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoimmunity
Share to Coxsackievirus Infections
Share to Diabetes Mellitus, Type 1
Share to Interferon-Induced Helicase, IFIH1
Share to Interferon Regulatory Factor-1
Share to Interferons
Share to Islets of Langerhans
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Source

Open in PubMed Open full text

Identifiers

PMID: 28000722
DOI: 10.1038/srep39378
PMCID: PMC5175199

Genes

IFIH1

Variants

rs1990760
rs1990760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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