Article

Stress-induced endogenous-dsRNAs drive beta-cells to IFN-I state

2023-11-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Aims/hypothesis</h4> Endogenous dsRNAs originating from retrotransposons within the human genome have the potential to trigger autoimmunogenic recognition via RIG-like receptors such as MDA5. This phenomenon, known as “viral mimicry”, induces potent interferon-beta expression, resulting in cell death and potential collateral death to surrounding cells. Viral mimicry has been mostly studied...

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Literature Corpus work: 776b29ba-ffad-5356-a63a-03fe3b72bd94
DOI: 10.1101/2023.11.10.566600

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