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Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates

4 May 2025

Abstract excerpt

Thioredoxin-interacting protein (TXNIP) plays a role in regulating endoplasmic reticulum (ER) and oxidative stress, which disrupt glucose homeostasis in diabetes. However, the impact of TXNIP deficiency on the differentiation and functionality of human stem cell-derived somatic metabolic cells remains unclear. We used CRISPR-Cas12a genome editing to generate TXNIP-deficient ( TXNIP −/− ) H1 human embryonic stem...

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PMID: 40320524
DOI: 10.1186/s13287-025-04314-5

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