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Article

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.

Science (New York, N.Y.) - 17 Apr 2009

Nejentsev Sergey, Walker Neil, Riches David, Egholm Michael, Todd John A

Abstract excerpt

Genome-wide association studies (GWASs) are regularly used to map genomic regions contributing to common human diseases, but they often do not identify the precise causative genes and sequence variants. To identify causative type 1 diabetes (T1D) variants, we resequenced exons and splice sites of 10 candidate genes in pools of DNA from 480 patients and 480 controls and tested their disease association in over...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon-Induced Helicase, IFIH1

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Source

Open in PubMed Open full text

Identifiers

PMID: 19264985
DOI: 10.1126/science.1167728
PMCID: PMC2707798

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.PMID 19264985Read ↗

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.Semantic proximity Read ↗

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Reduced expression of the MDA5 Gene IFIH1 prevents autoimmune diabetes.Semantic proximity Read ↗

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The association between the IFIH1 locus and type 1 diabetes.Semantic proximity Read ↗

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells.Semantic proximity Read ↗

Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes.Semantic proximity Read ↗

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent mannerSemantic proximity Read ↗

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Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-β production in peripheral blood mononuclear cells of type 1 diabetes patients.Semantic proximity Read ↗

Cumulative effect of IFIH1 variants and increased gene expression associated with type 1 diabetes.Semantic proximity Read ↗

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