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Article

Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.

Current diabetes reports - 1 Nov 2015

Looney Benjamin M, Xia Chang-Qing, Concannon Patrick, Ostrov David A, Clare-Salzler Michael J

Abstract excerpt

Recent evidence has highlighted the role of the innate immune system in type 1 diabetes (T1D) pathogenesis. Specifically, aberrant activation of the interferon response prior to seroconversion of T1D-associated autoantibodies supports a role for the interferon response as a precipitating event toward activation of autoimmunity. Melanoma differentiation-associated protein 5 (MDA5), encoded by IFIH1, mediates the...

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Share to DEAD-box RNA Helicases
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to IFIH1 gene

Share to Genetic Predisposition to Disease

Share to Interferon-Induced Helicase, IFIH1

Share to Polymorphism, Single Nucleotide

Share to Signal Transduction

Source

Identifiers

PMID: 26385483
DOI: 10.1007/s11892-015-0656-8

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.PMID 26385483Read ↗

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