Article
Reduced expression of IFIH1 is protective for type 1 diabetes.
PloS one - 9 Sept 2010
Downes Kate, Pekalski Marcin, Angus Karen L, Hardy Matthew, Nutland Sarah, Smyth Deborah J, Walker Neil M, Wallace Chris, Todd John A
Abstract excerpt
IFIH1 (interferon induced with helicase C domain 1), also known as MDA5 (melanoma differentiation-associated protein 5), is one of a family of intracellular proteins known to recognise viral RNA and mediate the innate immune response. IFIH1 is causal in type 1 diabetes based on the protective associations of four rare variants, where the derived alleles are predicted to reduce gene expression or function....
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