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Article

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner.

Frontiers in immunology - 1 Jan 2024

Stock Amanda J, Gonzalez Paredes Pierina, de Almeida Luciana Previato, Kosanke Stanley D, Chetlur Srinivaas, Budde Hannah, Wakenight Paul, Zwingman Theresa A, Rosen Aaron B I, Allenspach Eric J, Millen Kathleen J, Buckner Jane H, Rawlings David J, Gorman Jacquelyn A

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic islet β-cells are attacked by the immune system, resulting in insulin deficiency and hyperglycemia. One of the top non-synonymous single-nucleotide polymorphisms (SNP) associated with T1D is in the interferon-induced helicase C domain-containing protein 1 (IFIH1), which encodes an anti-viral cytosolic RNA sensor. This SNP results in an alanine to...

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Share to Autoimmune Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DEAD-box RNA Helicases

Share to Diabetes Mellitus, Type 1

Share to Interferon-Induced Helicase, IFIH1

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Identifiers

PMID: 38487540
DOI: 10.3389/fimmu.2024.1349601
PMCID: PMC10937421

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