Article

Spatial Multi-Omics Identifies Early Synaptic Pruning and Context-Specific Dopaminergic Vulnerability in Synucleinopathies

2025-11-06

Abstract excerpt

<title>Abstract</title> <p> The molecular events that precede overt neurodegeneration in Parkinson’s disease (PD) remain poorly defined. Incidental Lewy body disease (iLBD)—a prodromal state marked by brainstem-predominant Lewy pathology in the absence of clinical symptoms—offers a unique window into early pathogenesis. Here, we applied a multi-omic spatial profiling approach, integrating transcriptomics, proteo...

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Literature Corpus work: 3dafb1d0-6c88-50c6-9f93-c6c47610e665
DOI: 10.21203/rs.3.rs-7852229/v1

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