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Article

Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway.

Frontiers in immunology - 1 Jan 2021

Uriarte Huarte Oihane, Kyriakis Dimitrios, Heurtaux Tony, Pires-Afonso Yolanda, Grzyb Kamil, Halder Rashi, Buttini Manuel, Skupin Alexander, Mittelbronn Michel, Michelucci Alessandro

Abstract excerpt

Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly reacting to various pathological stimuli to maintain CNS homeostasis. However, microglial reactions in the CNS may also worsen neurological disorders. Hence, the phenotypic analysis of microglia in healthy tissue may identify specific poised subsets ultimately supporting or harming the neuronal network. This is all the...

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Source

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Identifiers

PMID: 33854507
DOI: 10.3389/fimmu.2021.639613
PMCID: PMC8039119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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