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Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies

24 Feb 2023

Abstract excerpt

Isolated rapid eye movement sleep behaviour disorder (iRBD) is a sleep disorder characterized by the loss of rapid eye movement sleep muscle atonia and the appearance of abnormal movements and vocalizations during rapid eye movement sleep. It is a strong marker of incipient synucleinopathy such as dementia with Lewy bodies and Parkinson's disease. Patients with iRBD already show brain changes that are reminiscent...

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PMID: 36826230
DOI: 10.1093/brain/awad044

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