Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies.

doi:10.1016/j.stemcr.2020.06.001

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Article

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies.

Stem cell reports - 14 Jul 2020

Pomeshchik Yuriy, Klementieva Oxana, Gil Jeovanis, Martinsson Isak, Hansen Marita Grønning, de Vries Tessa, Sancho-Balsells Anna, Russ Kaspar, Savchenko Ekaterina, Collin Anna, Vaz Ana Rita, Bagnoli Silvia, Nacmias Benedetta, Rampon Claire, Sorbi Sandro, Brites Dora, Marko-Varga György, Kokaia Zaal, Rezeli Melinda, Gouras Gunnar K, Roybon Laurent

Abstract excerpt

The hippocampus is important for memory formation and is severely affected in the brain with Alzheimer disease (AD). Our understanding of early pathogenic processes occurring in hippocampi in AD is limited due to tissue unavailability. Here, we report a chemical approach to rapidly generate free-floating hippocampal spheroids (HSs), from human induced pluripotent stem cells. When used to model AD, both APP and...

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PMID: 32589876
DOI: 10.1016/j.stemcr.2020.06.001
PMCID: PMC7363942

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