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Article

Dissecting the complexities of Alzheimer disease with in vitro models of the human brain.

Nature reviews. Neurology - 1 Jan 2022

Blanchard Joel W, Victor Matheus B, Tsai Li-Huei

Abstract excerpt

Alzheimer disease (AD) is the most prevalent type of dementia. It is marked by severe memory loss and cognitive decline, and currently has limited effective treatment options. Although individuals with AD have common neuropathological hallmarks, emerging data suggest that the disease has a complex polygenic aetiology, and more than 25 genetic loci have been linked to an elevated risk of AD and dementia....

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PMID: 34750588
DOI: 10.1038/s41582-021-00578-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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