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Article

Aging phenotype in AD brain organoids: Track to success and challenges.

Ageing research reviews - 1 Apr 2024

Hossain Muhammad Kamal, Kim Hyung-Ryong, Chae Han Jung

Abstract excerpt

Alzheimer's disease (AD) poses a complex challenge, with abnormal protein accumulation in the brain causing memory loss and cognitive decline. Traditional models fall short in AD research, prompting interest in 3D brain organoids (BOs) from human stem cells. These findings hold promise for unveiling the mechanisms of AD, especially in relation to aging. However, an understanding of the aging impact of AD remains...

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PMID: 38460555
DOI: 10.1016/j.arr.2024.102256

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