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Article

Pushing the boundaries of brain organoids to study Alzheimer's disease.

Trends in molecular medicine - 1 Aug 2023

Cerneckis Jonas, Bu Guojun, Shi Yanhong

Abstract excerpt

Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining how complex cell-cell interactions become dysregulated in AD requires novel human cell-based in vitro platforms that could recapitulate the intricate cytoarchitecture and cell diversity of the human brain. Brain organoids (BOs) are...

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Identifiers

PMID: 37353408
DOI: 10.1016/j.molmed.2023.05.007
PMCID: PMC10374393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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