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Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technology

24 Apr 2024

Abstract excerpt

BACKGROUND: Cerebral organoids (COs) are the most advanced in vitro models that resemble the human brain. The use of COs as a model for Alzheimer's disease (AD), as well as other brain diseases, has recently gained attention. This study aimed to develop a human AD CO model using normal human pluripotent stem cells (hPSCs) that recapitulates the pathological phenotypes of AD and to determine the usefulness of this...

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PMID: 38659053
DOI: 10.1186/s13287-024-03732-1

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