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Article

Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease.

Scientific reports - 24 Aug 2023

Lavekar Sailee S, Harkin Jade, Hernandez Melody, Gomes Cátia, Patil Shruti, Huang Kang-Chieh, Puntambekar Shweta S, Lamb Bruce T, Meyer Jason S

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and neurodegeneration. The retina is an extension of the central nervous system within the eye, sharing many structural similarities with the brain, and previous studies have observed AD-related phenotypes within the retina. Three-dimensional...

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Identifiers

PMID: 37620502
DOI: 10.1038/s41598-023-40382-4
PMCID: PMC10449801

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