Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.

PloS one - 1 Jan 2016

Raja Waseem K, Mungenast Alison E, Lin Yuan-Ta, Ko Tak, Abdurrob Fatema, Seo Jinsoo, Tsai Li-Huei

Abstract excerpt

The dismal success rate of clinical trials for Alzheimer's disease (AD) motivates us to develop model systems of AD pathology that have higher predictive validity. The advent of induced pluripotent stem cells (iPSCs) allows us to model pathology and study disease mechanisms directly in human neural cells from healthy individual as well as AD patients. However, two-dimensional culture systems do not recapitulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomes

Share to Induced Pluripotent Stem Cells

Share to Organoids

Share to Phosphorylation

Share to tau Proteins

Share to Tissue Scaffolds

Source

Open in PubMed Open full text

Identifiers

PMID: 27622770
DOI: 10.1371/journal.pone.0161969
PMCID: PMC5021368

Genes

APP
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.PMID 27622770Read ↗

Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technologySemantic proximity Read ↗

Simple modeling of Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technologySemantic proximity Read ↗

Alzheimer's disease in a dish: promises and challenges of human stem cell models.Semantic proximity Read ↗

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies.Semantic proximity Read ↗

Modeling familial Alzheimer's disease with induced pluripotent stem cells.Semantic proximity Read ↗

Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic PropertiesSemantic proximity Read ↗

Reprogramming the Brain—iPSC Models Illuminating the Pathogenesis and Treatment of Alzheimer’s Disease and Other DementiasSemantic proximity Read ↗

Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.Semantic proximity Read ↗

Generation of an Alzheimer’s Disease Model Derived from Induced Pluripotent Stem Cells with an APP Gene MutationSemantic proximity Read ↗

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem CellsSemantic proximity Read ↗

Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer's disease.Semantic proximity Read ↗

3D bioengineered neural tissue generated from patient-derived iPSCs develops time-dependent phenotypes and transcriptional features of Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.