Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells.

Tissue engineering. Part A - 1 Jul 2018

Yan Yuanwei, Song Liqing, Bejoy Julie, Zhao Jing, Kanekiyo Takahisa, Bu Guojun, Zhou Yi, Li Yan

Abstract excerpt

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders and causes cognitive impairment and memory deficits of the patients. The mechanism of AD is not well known, due to lack of human brain models. Recently, mini-brain tissues called organoids have been derived from human induced pluripotent stem cells (hiPSCs) for modeling human brain development and neurological diseases. Thus, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Microenvironment

Share to Cerebral Cortex

Share to Nerve Degeneration

Share to Organoids

Share to Spheroids, Cellular

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29361890
DOI: 10.1089/ten.TEA.2017.0423
PMCID: PMC6033307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells.PMID 29361890Read ↗

Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug DiscoverySemantic proximity Read ↗

Simple modeling of Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technologySemantic proximity Read ↗

Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technologySemantic proximity Read ↗

Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease.Semantic proximity Read ↗

Stem Cell Therapies in Alzheimer’s Disease: Applications for Disease ModelingSemantic proximity Read ↗

Pushing the boundaries of brain organoids to study Alzheimer's disease.Semantic proximity Read ↗

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies.Semantic proximity Read ↗

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.Semantic proximity Read ↗

Aging phenotype in AD brain organoids: Track to success and challenges.Semantic proximity Read ↗

Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?Semantic proximity Read ↗

Alzheimer's disease in a dish: promises and challenges of human stem cell models.Semantic proximity Read ↗

A 3D human brain–like tissue model of herpes-induced Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.