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Article

Regulation of C. elegans life-span by insulinlike signaling in the nervous system.

Science (New York, N.Y.) - 6 Oct 2000

Wolkow C A, Kimura K D, Lee M S, Ruvkun G

Abstract excerpt

An insulinlike signaling pathway controls Caenorhabditis elegans aging, metabolism, and development. Mutations in the daf-2 insulin receptor-like gene or the downstream age-1 phosphoinositide 3-kinase gene extend adult life-span by two- to threefold. To identify tissues where this pathway regulat...

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Identifiers

PMID: 11021802
DOI: 10.1126/science.290.5489.147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11021802-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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