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Article

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.

Nature communications - 24 Sept 2021

Park Hae-Eun H, Hwang Wooseon, Ham Seokjin, Kim Eunah, Altintas Ozlem, Park Sangsoon, Son Heehwa G, Lee Yujin, Lee Dongyeop, Heo Won Do, Lee Seung-Jae V

Abstract excerpt

Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous species. In Caenorhabditis elegans, mutations in the daf-2/insulin/IGF-1 receptor dramatically increase lifespan and immunity, but generally impair motility, growth, and reproduction. Whether these pleiotropic effects can be dissociated at a specific step in insulin/IGF-1 signaling pathway remains unknown. Through performing a...

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Identifiers

PMID: 34561453
DOI: 10.1038/s41467-021-25920-w
PMCID: PMC8463539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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