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Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegans

20 Mar 2012

Abstract excerpt

The DAF-2 Insulin/IGF-1 signaling (IIS) pathway is a strong modifier of Caenorhabditis elegans longevity and healthspan. As aging is the greatest risk factor for developing neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), we were interested in determining if DAF-2 signaling modifies disease pathology in mutant superoxide dismutase 1 (SOD1) expressing C. elegans. Worms with pan-neuronal G85R...

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PMID: 22457769
DOI: 10.1371/journal.pone.0033494

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