Article

Manipulation of alternative splicing of <i>IKZF1</i> elicits distinct gene regulatory responses in T cells

2024-11-06

Abstract excerpt

Genome-wide studies have identified significant allelic associations between genetic variants in or near the IKZF1 gene and multiple autoimmune disorders. IKZF1 , encoding the transcription factor IKAROS, produces at least 10 distinct transcripts. To explore the impact of alternative splicing of IKZF1 on the function of mature T cells, we generated a panel of human T-cell clones with truncating mutations in IK...

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Literature Corpus work: 3ca1cc94-5480-517a-8bf1-53d7eae016a0
DOI: 10.1101/2024.11.05.622018

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