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Article

IKAROS-Associated Diseases in 2020: Genotypes, Phenotypes, and Outcomes in Primary Immune Deficiency/Inborn Errors of Immunity.

Journal of clinical immunology - 1 Jan 2021

Kuehn Hye Sun, Nunes-Santos Cristiane J, Rosenzweig Sergio D

Abstract excerpt

IKAROS, encoded by IKZF1, is a zinc finger transcription factor and a critical regulator of hematopoiesis. Mutations in IKZF1 have been implicated in immune deficiency, autoimmunity, and malignancy in humans. Somatic IKZF1 loss-of-function mutations and deletions have been shown to increase predisposition to the development of B cell acute lymphoblastic leukemia (B-ALL) and associated with poor prognosis. In the...

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PMID: 33392855
DOI: 10.1007/s10875-020-00936-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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