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Article

Get Spliced: Uniting Alternative Splicing and Arthritis.

International journal of molecular sciences - 25 Jul 2024

van Haaren Maurice J H, Steller Levina Bertina, Vastert Sebastiaan J, Calis Jorg J A, van Loosdregt Jorg

Abstract excerpt

Immune responses demand the rapid and precise regulation of gene protein expression. Splicing is a crucial step in this process; ~95% of protein-coding gene transcripts are spliced during mRNA maturation. Alternative splicing allows for distinct functional regulation, as it can affect transcript degradation and can lead to alternative functional protein isoforms. There is increasing evidence that splicing can...

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PMID: 39125692
DOI: 10.3390/ijms25158123
PMCID: PMC11311815

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