Article

A de novo IKZF4 variant impairs marginal zone B cells and regulatory T cells by downregulating the NF-κB pathway

2025-06-18

Abstract excerpt

<title>Abstract</title> <p>Purpose Inborn errors of immunity (IEI) are a group of complex diseases characterized by reduced immunity and increased susceptibility to external pathogens, autoinflammation, autoimmune conditions, and/or malignancy. The IKAROS zinc-finger (<italic>IKZF</italic>) family belongs to the C2H2 zinc-finger transcription factors composed of IKAROS (<italic>IKZF1</italic>), HELIOS (<italic>I...

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Literature Corpus work: 89d5757a-ec3e-55fa-b402-1c2be2226cc8
DOI: 10.21203/rs.3.rs-6647352/v1

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