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Article

Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes.

Genome research - 1 Nov 2017

Newman Jeremy R B, Conesa Ana, Mika Matthew, New Felicia N, Onengut-Gumuscu Suna, Atkinson Mark A, Rich Stephen S, McIntyre Lauren M, Concannon Patrick

Abstract excerpt

Genome-wide association studies (GWAS) have identified multiple, shared allelic associations with many autoimmune diseases. However, the pathogenic contributions of variants residing in risk loci remain unresolved. The location of the majority of shared disease-associated variants in noncoding regions suggests they contribute to risk of autoimmunity through effects on gene expression in the immune system. In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29025893
DOI: 10.1101/gr.217984.116
PMCID: PMC5668939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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