Article
Fragile nucleosomes are essential for RNA Polymerase II to transcribe in eukaryotes
2025-10-11
Abstract excerpt
Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing caused by the +1 nucleosome in metazoans. We hypothesized that “pan-acetylated nucleosomes” along gene bodies are fragile and are generated to resolve the resistance of nucleosomes to the elongation of Pol II. To confirm...
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Identifiers and source
- Literature Corpus work
- e1426a45-482d-569f-b556-d9bb3ded0ccb
- DOI
- 10.1101/2025.10.08.681188