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Capturing the complexity of topologically associating domains through multi-feature optimization

2021-01-05

Abstract excerpt

The three-dimensional structure of human chromosomes is tied to gene regulation and replication timing, but there is still a lack of consensus on the computational and biological definitions for chromosomal substructures such as topologically associating domains (TADs). TADs are described and identified by various computational properties leading to different TAD sets with varying compatibility with biological pro...

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Literature Corpus work
27037a62-7d9c-5668-af09-f9430368d564
DOI
10.1101/2021.01.04.425264
Open publication

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Capturing the complexity of topologically associating domains through multi-feature optimizationDOI 10.1101/2021.01.04.425264
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