Article

Diverse functions associate with trans-species polymorphisms in humans

2021-01-22

Abstract excerpt

Long-term balancing selection (LTBS) can maintain allelic variation at a locus over millions of years and through speciation events. Variants shared between species, hereafter “trans-species polymorphisms” (TSPs), often result from LTBS due to host-pathogen interactions. For instance, the major histocompatibility complex (MHC) locus contains TSPs present across primates. Several hundred TSPs have been identified i...

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Literature Corpus work: 3b71b534-28b1-56e1-893c-77de0925763f
DOI: 10.1101/2021.01.21.427090

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