Article
Multiple instances of ancient balancing selection shared between humans and chimpanzees.
Science (New York, N.Y.) - 29 Mar 2013
Leffler Ellen M, Gao Ziyue, Pfeifer Susanne, Ségurel Laure, Auton Adam, Venn Oliver, Bowden Rory, Bontrop Ronald, Wall Jeffrey D, Sella Guy, Donnelly Peter, McVean Gilean, Przeworski Molly
Abstract excerpt
Instances in which natural selection maintains genetic variation in a population over millions of years are thought to be extremely rare. We conducted a genome-wide scan for long-lived balancing selection by looking for combinations of SNPs shared between humans and chimpanzees. In addition to the major histocompatibility complex, we identified 125 regions in which the same haplotypes are segregating in the two...
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