Trans-species polymorphism in humans and the great apes is generally maintained by balancing selection that modulates the host immune response

doi:10.1186/s40246-015-0043-1

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Article

Trans-species polymorphism in humans and the great apes is generally maintained by balancing selection that modulates the host immune response

3 Sept 2015

Abstract excerpt

Known examples of ancient identical-by-descent genetic variants being shared between evolutionarily related species, known as trans-species polymorphisms (TSPs), result from counterbalancing selective forces acting on target genes to confer resistance against infectious agents. To date, putative TSPs between humans and other primate species have been identified for the highly polymorphic major histocompatibility...

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PMID: 26337052
DOI: 10.1186/s40246-015-0043-1

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