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Article

Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution.

Nature communications - 18 Jul 2024

Dietzen Michelle, Zhai Haoran, Lucas Olivia, Pich Oriol, Barrington Christopher, Lu Wei-Ting, Ward Sophia, Guo Yanping, Hynds Robert E, Zaccaria Simone, Swanton Charles, McGranahan Nicholas, Kanu Nnennaya

Abstract excerpt

During each cell cycle, the process of DNA replication timing is tightly regulated to ensure the accurate duplication of the genome. The extent and significance of alterations in this process during malignant transformation have not been extensively explored. Here, we assess the impact of altered replication timing (ART) on cancer evolution by analysing replication-timing sequencing of cancer and normal cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39019871
DOI: 10.1038/s41467-024-50107-4
PMCID: PMC11255325

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