Article

Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma

2026-03-25

Abstract excerpt

<title>Abstract</title> Oligodendroglioma is genetically defined by mutations in isocitrate dehydrogenase 1 or 2 (IDH1/IDH2) and 1p/19q codeletion. We previously showed that in IDH1-mutant oligodendroglioma, the oncometabolite D-2-hydroxyglutarate biases the sphingosine-1-phosphate–to–ceramide rheostat toward ceramides. Taking advantage of this intrinsic metabolic vulnerability, we investigated whether further...

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Literature Corpus work: 3ae2b93b-a9dd-510d-81a2-1948b14ff022
DOI: 10.21203/rs.3.rs-9077389/v1

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