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Article

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas.

Cancer research - 1 May 2018

Viswanath Pavithra, Radoul Marina, Izquierdo-Garcia Jose Luis, Ong Wei Qiang, Luchman Hema Artee, Cairncross J Gregory, Huang Bo, Pieper Russell O, Phillips Joanna J, Ronen Sabrina M

Abstract excerpt

Tumor metabolism is reprogrammed to meet the demands of proliferating cancer cells. In particular, cancer cells upregulate synthesis of the membrane phospholipids phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdE) in order to allow for rapid membrane turnover. Nonetheless, we show here that, in mutant isocitrate dehydrogenase 1 (IDHmut) gliomas, which produce the oncometabolite 2-hydroxyglutarate...

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Autophagy
Endoplasmic Reticulum
Gene Silencing
Glioma
Glutarates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

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Identifiers

PMID: 29358170
DOI: 10.1158/0008-5472.CAN-17-2926
PMCID: PMC5932252

Genes

IDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas.PMID 29358170Read ↗

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