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Article

IDH status dictates oHSV mediated metabolic reprogramming affecting anti-tumor immunity.

Nature communications - 24 Apr 2025

Sahu Upasana, Mullarkey Matthew P, Murphy Sara A, Anderson Joshua C, Putluri Vasanta, Kamal Abu Hena Mostafa, Park Jun Hyoung, Lee Tae Jin, Ling Alexander L, Kaipparettu Benny A, Sharma Ashok, Putluri Nagireddy, Wenzel Pamela L, Willey Christopher D, Chiocca E Antonio, Markert James M, Kaur Balveen

Abstract excerpt

Identification of isocitrate dehydrogenase (IDH) mutations has uncovered the crucial role of metabolism in gliomagenesis. Oncolytic herpes virus (oHSV) initiates direct tumor debulking by tumor lysis and activates anti-tumor immunity, however, little is known about the role of glioma metabolism in determining oHSV efficacy. Here we identify that oHSV rewires central carbon metabolism increasing glucose...

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Identifiers

PMID: 40274791
DOI: 10.1038/s41467-025-58911-2
PMCID: PMC12022073

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ACSL4

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