Article

SCD1 inhibition synergizes with TMZ to improve IDH1 <sup>MUT</sup> glioma survival of mice via lipotoxic stress

2026-06-12

Abstract excerpt

Mutations in the isocitrate dehydrogenase enzyme (IDH1) are prevalent in low-grade gliomas, such as oligodendrogliomas. Other than surgery, radiation, and chemotherapy, few options for treatment exist. The standard of care for patients currently consists of maximal safe resection, as well as the potential use of radiation and chemotherapy, typically followed by radiographic surveillance. Although significant advan...

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Literature Corpus work: c9936ad7-4bd8-5200-b94f-6151495290bf
DOI: 10.64898/2026.06.09.731222

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