Article

<i>SMPD3</i> suppresses IDH mutant tumor growth via dual autocrine-paracrine roles

2020-07-14

Abstract excerpt

Isocitrate dehydrogenase (IDH) mutant gliomas, including oligodendroglioma (IDH-O) and astrocytoma (IDH-A), have signature slow-growth rates that are poorly understood. Here, we reveal that SMPD3, a ceramide-producing sphingomyelinase implicated as a tumor suppressor gene and involved in extracellular vesicle biogenesis, suppresses IDH-mutant tumor growth via autocrine and paracrine actions. In patients with IDH-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7210ae5-3d04-516d-8b20-f34c4fdead8d
DOI: 10.1101/2020.07.14.202200

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>SMPD3</i> suppresses IDH mutant tumor growth via dual autocrine-paracrine rolesDOI 10.1101/2020.07.14.202200Read

SMPD3-mediated extracellular vesicle biogenesis inhibits oligodendroglioma growthSemantic proximity Read

Targeting the Sphingolipid Rheostat in GliomasSemantic proximity Read

Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant OligodendrogliomaSemantic proximity Read

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer HallmarksSemantic proximity Read

Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like state and insights into progressionSemantic proximity Read

Autophagy–Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in GliomaSemantic proximity Read

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas.Semantic proximity Read

Microglial lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerabilitySemantic proximity Read

Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growthSemantic proximity Read

Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth.Semantic proximity Read

SCD1 inhibition synergizes with TMZ to improve IDH1 <sup>MUT</sup> glioma survival of mice via lipotoxic stressSemantic proximity Read

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cellsSemantic proximity Read