Article

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids

2020-03-20

Abstract excerpt

<h4>Summary</h4> Cytosolic IDH1 enzyme plays a key, but currently unexplored, role in lipid biosynthesis. Using Raman imaging microscopy, we identified heterogeneous lipid profiles in cellular organelles attributed uniquely to IDH1 mutations. Via organelle lipidomics, we found an increase in saturated and monounsaturated fatty acids in the endoplasmic reticulum of IDH1 mut cells compared with IDH WT glioma. We...

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Literature Corpus work: 82bd9b97-2f89-5f15-a0cd-94da0c63528a
DOI: 10.1101/2020.03.20.000414

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