Article

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors

2024-04-29

Abstract excerpt

Oligodendroglioma is genetically defined as a tumor harboring isocitrate dehydrogenase 1 or 2 mutations (IDH1 mut /IDH2 mut ) and 1p/19q co-deletions. Previously, we reported that in IDH1 mut gliomas, D-2HG, the product of IDH1 mutant enzyme produces an increase in monounsaturated fatty acid levels that are incorporated into ceramides, tilting the S1P-to-ceramide rheostat toward apoptosis. Herein, we exploited...

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Literature Corpus work: cafa43cc-fd90-5830-9aa8-1562284c9c5e
DOI: 10.1101/2024.04.27.591426

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