Article

Autophagy–Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma

2026-01-07

Abstract excerpt

Glioma progression and resistance to temozolomide (TMZ) remain major clinical challenges. Here, we investigated whether dysregulated autophagy and cholesterol metabolism are coordinately remodeled during glioma progression and TMZ resistance. Tissue microarray analysis of astrocytoma and glioblastoma specimens revealed progressive autophagosome accumulation, reflected by increased LC3β puncta, coupled with impaire...

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Literature Corpus work: 93793c3f-b518-5fcb-b8d4-f13da6313b38
DOI: 10.64898/2026.01.06.697885

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